A Sled Dog Model for Positive Health Effects of Weight Management and Exercise

Obesity is a significant risk factor for metabolic syndrome and type II diabetes. Physical activity and/or dietary modification can reduce the incidence of obesity. Marginal fitness levels limit efficacy exercise training, most humans choose from wide range strategies to lose weight. Despite these limitations, in absence weight loss may offer protective benefits against development To examine training with without loss, we measured changes indices conjunction moderate body gain, no intended change weight, bodyweight reduction healthy canine model. We glucose transporter 4 on peripheral blood mononuclear cells, plasma glucose, hemoglobin A1c, tumor necrosis factor-alpha, interleukin 6, insulin before, during, after exercise, loss. Weight gain increased while by 4% cells. also observed 4, factor-α which be indicative reduced sensitivity potentially due high energy demand coupled low caloric availability.